Thursday, December 19, 2013

SMILES

SMILE

Today, we learned about SMILE notation that can be used in chemsketch application. Below are the example of SMILE quotation and its molecular structure.


Picture of SMILE notation and its molecular structure

What is SMILE?

The simplified molecular-input line-entry system or SMILES is a specification in form of a line notation for describing the structure of chemical molecules using short ASCII STRINGS. SMILES strings can be imported by most molecule editors  for conversion back into two dimensional drawings of three dimensional models of the molecules. We draw our SMILES using a specific program name CHEMSKETCH.



Some examples of application on SMILES notations



SMILES Name SMILES Name
CCEthane[OH3]+ Hydronium ion
O=C=O Carbon Dioxide [2H]O[2H] Dueterium Oxide
C#N Hydrogen Cyanide [235U] Uranium-235
c1ccccc1 Benzene F/C=C\F Z-difloroethane

Summary

Simplified Molecular Input Line Entry System (SMILES) Widely used AND computationally efficient Uses atomic symbols and a set of intuitive rules Uses hydrogen-suppressed molecular graphs (HSMG)

SMILESCAS Database
The PowerPoint version on this note. (More Detailed)

Other Examples of SMILES notation and its Molecular structure







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